Prokinetic effect of erythromycin on contractility of an isolated strip of rabbit's intestine compared with neostigmine and metoclopramide

Intestinal hypomotility is a major problem after surgery on gastrointestinal tract and in certain conditions. Prokinetic effect of erythromycin on ILEAL contractility on an isolated strip of rabbit's intestine was compared with that of neostigmine and metoclopramide. Effect of neostigmine is highly significant [P > 0.001] in increasing contractility in intestinal muscle strips Metoclopramide effectively increased contractility [P > 0.1] and erythromycin also significantly [P > 0.05] improved contractility. This study proved that erythromycin is a potent Prokinetic agent, which can be useful in conditions associated with gastrointestinal hypomotility

Effect of HMG on ovarian folliculogenesis with and without pituitary down-regulation

comparison of ovarian follicular development using hMG stimulation with and without pituitary downregulation by a GnRH analogue. Design: A prospective study. Setting: At The Infertility Advisory Center, a private setup specializing in assisted methods of conception. Subjects: Sixty women selected to undergo in vitro fertilization [IVF] treatment for infertility for various indications. the patients were alternately assigned to one of the two protocols of ovarian stimulation the follicular development was monitored by serial vaginal ultrasonography and E[2] estimations. Stimulation cycles with suboptimal response were canceled. The patients in the two groups matched for age. In the completed cycles of treatment follicular development was comparable in both the protocols with regard to size, number and E[2] levels. Follicular growth in pituitary downregulated cycles was delayed but cycle cancellation rate was lower. hMG stimulation of ovaries with pituitary downregulation reduces the cycle cancellation rate but requiring longer administration of hMG increases the cost of treatment

Induction labour with prostaglandin E[2] vaginal tablets

Prostaglandins E[2] and F[2] alpha cause softening and bring about uterine contractions and are used to induce labour or abortion being given by various routes. For the past few years 3 mg of vaginal tablets of Prostaglandin E[2] have become available in Pakistan. To assess the efficiency of this preparation in induction of labour in Pakistani women, a prospective study was carried out in 50 patients: 40 multigravida 10 primigravidas. After ascertaining the indication for induction and ruling out any contraindication to vaginal delivery, 3 mg vaginal tablet of prostaglandin E[2] was placed in the vagina. If labour did not initiate, the tablet was repeated at six hour intervals for a total dose of 9 mg. There was significant softening of the cervix. Thirty one of the 40 multigravida and six of the 10 primigravida delivered within 24 hours giving a success rate of 75% and 60% respectively. The authors conclude that induction of labour with prostaglandin E[2] vaginal tablets is a safe and simple method giving a good success rate without undue side effects